How does milbemax work on cats? - briefly
Milbemycin oxime, the active ingredient in Milbemax, works by inhibiting the production of essential proteins in parasites, leading to their paralysis and eventual death. This treatment is effective against both internal (intestinal worms) and external parasites (fleas) in cats.
How does milbemax work on cats? - in detail
Milbemycin oxime, the active ingredient in Milbemax, is a macrocyclic lactone that works by inhibiting the production of essential proteins in parasites, ultimately leading to their death. When administered to cats, Milbemycin oxime targets three primary groups of internal parasites: nematodes (roundworms), cestodes (tapeworms), and lungworms.
The mechanism of action begins with the absorption of Milbemycin oxime into the bloodstream through the gastrointestinal tract. Once in the bloodstream, it is distributed throughout the body, including vital organs such as the liver and lungs. The primary mode of action involves binding to specific receptors on the parasites' muscle cells, causing an increase in the permeability of the cell membrane. This leads to a disruption in the transport of ions across the membrane, which is crucial for the survival and motility of the parasite.
In nematodes, Milbemycin oxime inhibits the release of neurotransmitters, particularly acetylcholine, from nerve endings. This causes paralysis and eventual death of the worms. For cestodes, the drug disrupts the glucose metabolism pathway, leading to a depletion of energy reserves and subsequent death of the parasite. In lungworms, Milbemycin oxime affects the neuromuscular transmission, causing paralysis and death of the worms.
In addition to its direct effect on parasites, Milbemycin oxime also stimulates the host's immune system. This secondary effect helps in controlling the infection by enhancing the body's natural defenses against re-infestation. The drug is highly effective and provides broad-spectrum protection against a wide range of internal parasites that can affect cats, making it an essential component of feline parasite control programs.
Milbemycin oxime is well-tolerated by cats, with minimal side effects reported. However, as with any medication, it is important to follow the prescribed dosage and administration guidelines to ensure optimal effectiveness and safety. Regular use of Milbemax, in conjunction with other preventive measures such as routine fecal examinations and environmental hygiene, can significantly reduce the risk of parasitic infections in cats, contributing to their overall health and well-being.