A cat's de Ritis coefficient is lowered, what does it mean? - briefly
A lower de Ritis coefficient in a cat typically indicates elevated liver enzymes, suggesting potential liver damage or disease. This often necessitates further diagnostic evaluation by a veterinarian.
A cat's de Ritis coefficient is lowered, what does it mean? - in detail
The de Ritis ratio, also known as the AST/ALT ratio, is a diagnostic tool used in veterinary medicine to assess liver function and damage. It is calculated by dividing the serum activity of aspartate aminotransferase (AST) by that of alanine aminotransferase (ALT). In cats, a lowered de Ritis ratio can provide valuable insights into the animal's health status.
When the de Ritis ratio is decreased, it typically indicates that the levels of ALT in the blood are relatively higher compared to AST. This pattern often suggests specific conditions or states within the cat's body. One common cause for a lowered de Ritis ratio in cats is hepatic (liver) disease, particularly those affecting the hepatocytes (liver cells). Certain liver diseases can selectively increase ALT levels more than AST levels, leading to a decreased ratio.
However, it is crucial to note that the interpretation of the de Ritis ratio should not be done in isolation. Other clinical findings and laboratory results must be considered for a comprehensive diagnosis. For instance, concurrent elevations in other liver enzymes like alkaline phosphatase (ALP) or bilirubin may support a hepatic origin. Additionally, the de Ritis ratio can be influenced by non-hepatic factors such as muscle damage, which can also affect AST levels.
In summary, a lowered de Ritis coefficient in cats usually indicates an imbalance between liver enzymes, often pointing towards hepatic issues. However, a thorough evaluation that includes other clinical parameters is essential for accurate diagnosis and effective treatment planning. Veterinarians should use the de Ritis ratio as one of several tools to assess feline health comprehensively.